Cisplatin potassium wasting

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August undefined, 2024

Webis an uncommon genetic disorder characterized by renal potassium and sodium wasting, excessive production of renin and aldosterone, and normotension. Gitelman syndrome is caused by loss of function mutations in a thiazide-sensitive ion …

Hyperkalemia (High Potassium) - Managing Side Effects - Chemocare

WebClinical implications of potassium depletion Protective effect of potassium Hypokalemia Potassium supplementation strategies: prevention vs repletion Compliance issues and potassium replacement therapy Potassium repletion and the role of magnesium Consensus guidelines for the use of potassium replacement in clinical practice Article … WebRefractory Potassium Repletion due to Cisplatin-Induced Magnesium Depletion JAMA Internal Medicine JAMA Network • Cisplatin is a common cause of hypomagnesemia … can a cat think your its mother

Differential diagnosis of hyponatremia induced by …

WebJan 12, 2024 · A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia. J Clin … WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin … fish catching methods of the world

Cisplatin dosing, indications, interactions, adverse effects

Refractory potassium repletion due to cisplatin-induced ... - Pub…

WebApr 7, 2015 · Cisplatin-associated acute kidney injury (AKI) occurred in 8% of the patients. Urine neutrophil gelatinase-associated lipocalin to urine creatinine ratio (NGAL/Cr) and … Web42%–100% of patients depending on total cisplatin dose and length of exposure. Hypomagnesemia and renal magnesium wasting may persist for up to 6 years after initial dose (5). Renal salt wasting syndrome has been reported in up to 10% of patients, manifesting as hyponatremia and severe ortho-static hypotension in the setting of high … fish catching birds in seaWebJul 18, 2024 · In fact, Schilsky and colleagues showed that 22 of 29 patients (76%) who received cisplatin for non-seminomatous germ cell tumors developed acute hypomagnesemia; eleven (50%) remained hypomagnesemic for at least 3 years. 83 This long-term effect has been corroborated by other investigators as well. 84, 85 can a cat\\u0027s tail fall off

"WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38(12 ... " - Cisplatin potassium wasting

Cisplatin potassium wasting

Renal salt wasting in patients treated with high-dose cisplatin ...

WebFeb 5, 2014 · Cisplatin is one of the most potent and valuable chemotherapy agents available, and is used to treat a broad spectrum of malignancies, with cisplatin … WebCDDP-induced hyponatremia has also occurred in a case of renal salt-wasting syndrome, 4 in patients with nausea/vomiting/anorexia, and when vigorous hydration was administered to prevent nephrotoxicity. 5 It is sometimes difficult to accurately diagnose the cause of hyponatremia because various contributing factors can interact in a complex manner.

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WebMay 24, 2006 · Cisplatin is a well-known nephrotoxic antineoplastic drug. Chronic hypokalemic metabolic alkalosis with hypomagnesemia and hypocalciuria is one of the … WebJul 22, 2024 · Exposure of tubular cells to cisplatin activates complex signaling pathways that result in tubular cell injury and cell death. A robust inflammatory response, as well as …

WebMar 1, 2024 · cisplatin cyclosporine duloxetine lithium methotrexate methylphenidate NSAIDs, such as diclofenac, ibuprofen, or indomethacin sucralfate other medications that lower potassium. People taking oral medications for diabetes may need to talk to their doctor about adjusting the dose of their medicine. WebAug 16, 2024 · Cisplatin-associated electrolyte dysregulation is a prevalent therapy-related adverse effect. There are numerous electrolyte-supplemented hydration regimens that have been evaluated, however these studies focused on the development of nephrotoxicity.

WebOct 5, 2014 · 1. Introduction. Cisplatin (CAS No. 15663-27-1, MF-Cl 2 H 6 N 2 Pt; NCF-119875), cisplatinum, also called cis-diamminedichloroplatinum(II), is a metallic (platinum) coordination compound with a square planar geometry.It is a white or deep yellow to yellow-orange crystalline powder at room temperature. It is slightly soluble in water and soluble … Webbular dysfunction with sodium, potassium, and magne-sium wasting. Most patients have a reversible decrease in glomerular filtration, but some have an irreversible de- ... Cisplatin is accumulated by peritubular uptake in both the proximal and …

WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

WebDec 13, 2024 · The electrolytes affected are primarily mineral ions, specifically potassium, calcium, magnesium, sodium, and chloride. Fundamentally, like Bartter’s syndrome, Gitelman syndrome is a salt wasting nephropathy. The symptoms and severity of the disorder can vary greatly from one person to another and can range from mild to severe. can a cat take your breath awayWebCisplatin induces hypomagnesemia through its renal toxicity possibly by a direct injury to mechanisms of magnesium reabsorption in the ascending limb of the loop of Henle … fish catch the energyWebCisplatin is known to induce Fanconi syndrome and renal salt wasting (RSW). RSW typically only requires transient normal saline (NS) support. We report a severe RSW case that required 12 liters of 3% saline. A 57-year-old woman with limited stage small cell cancer was admitted for cisplatin (80 mg/m 2) and etoposide (100 mg/m 2) therapy. fish catch phrasesWebCisplatin Foscarnet Aminoglycosides: Laxatives/enemas Sodium polystyrene sulfonate: ... Renal potassium wasting is indicated by a 24-hour urine potassium level exceeding 15 to 30 mEq per L. can a cat\u0027s eyes change colorWebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal … fish caterers near meWebJul 18, 2024 · Cisplatin may cause hypomagnesemia by downregulating the TRPM6/EGF pathway. Of note, Mg co‐administration mitigates both cisplatin‐induced … fish catching video youtubeWebJul 20, 2024 · Since platinum agents are nephrotoxic, emetogenic and diarrheagenic, they have the potential to induce potassium wasting … can a cat\u0027s tail fall off