WebMay 1, 2007 · COX-2 catalyzes the transformation of arachidonic acid to prostaglandin H2, which is the rate-limiting step in the formation of prostaglandins (PGs) and thromboxane A2 (TXA2). COX-2 is a potent mediator of inflammation and is implicated in prostanoid signaling in activity dependent plasticity. WebDec 2, 2024 · PTGS2 is usually considered as a biomarker, but not as a driver, of ferroptosis. 27 However, PTGS2 may mediate ferroptosis in neural cells after traumatic injury in the …
Frontiers The Role of Prostaglandin-Endoperoxide …
WebProstaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (PTGS2) is a gene that encodes a protein that is the key enzyme in prostaglandin biosynthesis. Missense mutations, silent mutations, and nonsense mutations are observed in cancers such as skin cancer, colon cancer, and endometrial cancer. WebFeb 10, 2024 · Radiation therapy is a common treatment method for cancer, whereas radioresistance of cancer cells is a huge clinical problem. 21 Tumor radioresistance is a major reason for decreased efficiency of cancer radiation therapy. 22 Through the bioinformatics analysis of differential gene expression, PTGS2 was found highly … passing off of the storm
Breaking barriers for T cells by targeting the EPHA2/TGF-
WebSep 5, 2013 · PTGS2 has been shown to be expressed in most solid tumor types ( 2–5 ). PTGS2 upregulation seems to be particularly common in colorectal cancer, with approximately 85% of these tumors expressing PTGS2 compared with 20% of normal colorectal mucosal samples ( 6–8 ). WebPTGS2. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. WebFeb 14, 2024 · PTGES/PGE 2 signaling links immunosuppression and lung metastasis in Gprc5a -knockout mouse model Introduction. Tumor recurrence and metastasis are the … passing off remedies